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Children with medulloblastoma have a high mortality and morbidity. Long-term survivors are rare. The aim of this study was to review our experience with this difficult group of patients. Twenty-three patients with metastatic medulloblastoma who were treated with high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) between 1987 and 1998 were analysed retrospectively. Only three patients had a Karnofsky performance status > or = 90%. The median patient age was 9.5 years (range 3 to 19). The overall 2-year disease-free survival (DFS) was 41% with a 2-year event-free survival (EFS) of 33%. The initial DFS and EFS were not significantly different by: disease stage, primary surgery, age, sex, white blood cell count or PBSC dose. The 2-year DFS for patients with stable disease at initial chemotherapy ( or = 24 months from the first day of therapy. PBSCT followed by consolidation chemotherapy for metastatic medulloblastoma has long-term outcomes similar

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