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BMW is among the top companies that are always looking for ways to improve on their products.. Bmw Navigation V32.1 Software Update Download and Installation with USB.REIN is a chronic otitis media animal model that develops chronic fluid accumulation in the middle ear effusion and hearing loss. This model mimics several aspects of human otitis media with effusion (OME).
Design and methods:
Fourteen male CBA/N mice are used in this study. Three groups are formed according to surgical procedures. In group I (n= 7) the left external auditory canal (EAC) was left open and closed with silicone tape. In group II (n= 7) the left EAC was opened and both eardrums perforated with a 25G needle. In group III (n= 4), the same procedures were done on the left ears. In group I and group II, a serial weekly injection of 50μL of Pseudomonas aeruginosa (PA) suspension in phosphate buffered solution (0.1M, pH7.4) was given to the left auditory bulla after otoplasty. Sham procedures on both ears were performed as a control on each group. The animals are killed after 28 days of PA injection. The EACs are opened and examined for otitis media-like conditions.
Findings:
Group III (ears with otoplasty), no significant ear condition was observed in these ears. In group II, the ears showed otitis media-like condition with redness, swelling, and thin transparent membrane in the EAC lumen and massive inflammatory cell infiltration around the EAC wall. In contrast, otitis media-like condition was found in group I only, with some inflammation and redness were observed. Group I (hearing with left otoplasty) only, the tympanic membrane in the affected ears was red and swollen with transparent thin membrane in the EAC lumen and thick inflammatory cell infiltration around the EAC. A scalloped shape of the tympanic membrane was seen on the left ears of group I.
Conclusion:
This study found that otoplasty increased the otitis media-like condition in group I and II, and this animal model can be used to compare the ototoxicity of ototopical drugs and to study their ototoxicity.
This abstract was presented in the **Spring Symposium**, held in
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