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Subsequent to a study on the binding and release of the gp33 Ag on the surfaces of infected cells, it has been shown that gp33-TCR binds this Ag via its cysteine-rich domain ([@B46]). Furthermore, the gp33-TCR/Ag interaction specifically induces the expression of IL-2 and IL-4 genes via MAP kinase pathways ([@B46]). Within this study, it was shown that the binding of gp33-TCR to the Ag occurs after the association of the kinase and phosphatase to the TCR. Although this function is not a direct example of the ARD of MAPKs, it would suggest that the ARD regulates the binding of the kinase to the TCR and/or phosphatase, perhaps in a similar manner to that reported for ThiJ. However, if this were the case, then the gp33-TCR/Ag interaction would also be independent of the phosphorylation of the TCR.
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