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In this paper, we summarize the immunological characteristics of newborn in comparison with the adult. An analysis of these characteristics shows that there is a wide variation in the immunological status of newborns, mainly depending on the immunoglobulin subclass. The majority of newborns have low IgM and moderate IgA levels while IgG is always very high. Fc receptor and complement receptor levels are similar to adults. Neonatal lymphocytes have a great potential to differentiate as judged by their high rosette formation capacity, although their T-helper activity is low. On the other hand, neonatal B-cells have a great proliferative response to various mitogens. Despite the high T-helper cell activity in the newborn, they have a great propensity to produce anti-idiotype antibodies. The differences found between newborns and adults are mainly explained by the ontogenic development of the immune system in the perinatal period.Protein arginine methyltransferase 7 inhibitors as potential chemotherapeutic agents.
Protein arginine methyltransferase (PRMT) is a family of arginine methyltransferases that catalyse the symmetric dimethylation of the terminal nitrogen on histone tails, many transcription factors, RNA splicing factors, cell cycle regulators and non-histone nuclear proteins. PRMT7 is unique among PRMTs since its enzymatic activity is strictly dependent on the presence of its translocated partner transcription factor 7-like 2. PRMT7 has been implicated in a variety of cellular processes such as transcriptional regulation, cell proliferation, apoptosis, immune response and the regulation of cytoskeletal proteins. Importantly, PRMT7 is over-expressed in a variety of human cancers and has been shown to act as a proto-oncogene and as a marker of poor prognosis. Aberrant expression of PRMT7 is observed in a large percentage of malignancies, indicating that it could be a promising therapeutic target. To date, no PRMT7 inhibitors have been developed, although there are several compounds that act as PRMT5 inhibitors in development. However, none of them have been progressed into clinical trials. Therefore, discovery of potent and selective PRMT7 inhibitors is required for the development of anticancer drugs. In this review, we highlight PRMT7 as an attractive target for anticancer therapy. We describe the function of PRMT7, and then summarize the ongoing efforts to identify PRMT7-selective and -specific inhibitors.Q:
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