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If you’re new to Photoshop, be sure to take advantage of the “Getting to Know Photoshop” chapter. This chapter is the guide to learn the ins and outs of the software, from using the essential tools to the features that make the software unique. In this chapter, we get to know how Photoshop works on a more technical level, and we teach you how to perform some of the most common tasks. The first of these is the essential tools that you need to create a document with multiple layers and layers’ unique blending modes. We also show you how to dodge, burn, or clone existing layers. After you get the hang of these tools, we move on to show you ways to make adjustments to lighting, color, and exposure. We also take you through the special tools for working with canvas sizes. Finally, we move on to the advanced tools: selections, masks, layers, and paths. We show you how to use those tools for removing backgrounds, working with multiple layers, and vectorizing artwork. The more you understand how Photoshop works, the easier it will be to pick up new features as you advance. Understanding the Photoshop Toolbox The Photoshop toolbox is a group of command buttons and menu commands you can use to modify an image. The applications used to make each of the tools are organized by the category of the tool. You can select several tools to use at one time. To illustrate the tools, Figure 5-1 shows what the layer tools look like in the Layers palette. The tools are at the top of the Layers palette, which is the window used to modify the attributes of layers. **Figure 5-1:** The Photoshop toolbox is composed of buttons and menu commands. The Layers palette organizes tools by category. You can also rearrange the order of the tools in the palette using the tool’s options (see “Customizing tool functionality,” later in this chapter). The following list summarizes the tools available from the Photoshop toolbox: Presets: Use the Presets tool to modify the global settings for the toolbox, including its color scheme. Chapter 11 offers insights into global image adjustments. Selection: Select the image objects you want to use with the toolbox. The tools used in this section include the Rectangular Selection tool, the Selection Brush, and the Magic Wand. Chapter 6 covers the selection tools. Blur/Sharpen: Use



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Addictive behaviors often result from plastic changes in brain circuits that normally help regulate how we behave. These processes, which are called learning and memory, occur in many brain areas including the cortex and hippocampus. In the cortex, dopamine neurons are a key part of the brain’s reward system. Plasticity in dopamine circuits may underlie the repeated compulsion to feed in some people with compulsive overeating. However, it is not clear whether dopamine is involved in adaptive or maladaptive learning and memory in people with addictive behaviors. Here we report in human and mouse studies that the level of dopamine activity in reward circuits is elevated when addictive behaviors are self-reinforced. We find that normalizing dopamine transmission in the nucleus accumbens prevents and reverses the maladaptive overtraining of behaviors associated with addictive-like behavior. We also find that the reward-related activity of dopamine neurons is enhanced during overtraining of addictive behaviors in a way that is absent in healthy controls. Finally, we found that elevated levels of dopamine during reward-related learning impair subsequent learning about similar stimuli. Together, these findings show that elevated dopamine activity in reward circuits has a general and long-lasting impact on the experience and learning of addictive behaviors.[Salvage chemotherapy with S-1 in curatively resected rectal cancer: a cooperative study of the Japan Clinical Oncology Group (JCOG)]. Although patients with locally advanced or recurrent rectal cancer are candidates for potentially curative surgery, recurrence is common. High-intensity preoperative therapies might result in downstaging of the disease, thereby making surgery a potentially curative option. This study was designed to clarify the therapeutic role of S-1 (a new oral fluoropyrimidine derivative), a combination of 5-FU and MMC, in the preoperative treatment of curatively resected rectal cancer. The present study was a randomized, multicenter, prospective, clinical trial. In the S-1 arm, S-1 was administered orally at a daily dose of 40 mg/m(2) for 14 days, followed by 7 days of rest, starting 1 week before surgery. In the control arm, intravenous MMC 40 mg/m(2) was administered for 1 day and 5-FU 300 mg/m(2) for 5 days, followed by 7 days rest, starting 1 week before surgery. The regimen was repeated every 4 weeks for 2-3 cycles. In the S-1 arm, 25 patients were entered and 20 patients were treated



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Sir, A 60-year-old man presented with dull, non-tender, non-radiating, burning pain and impotence in both upper limbs associated with edema of face for 20 years. He also had history of loss of appetite, tremors and weakness of both lower limbs for the last 2 months. Local physical examination revealed decreased pitting edema, increased pulsatile, and bright red blood vessels over bony prominences \[[Figure 1](#F1){ref-type=”fig”}\]. Systemic examination was unremarkable. He had hypertension for which he was already on treatment. His hemogram, renal function test, lipid profile and serum vitamin B12 level were normal. Cerebral spinal fluid (CSF) examination revealed increased protein and lymphocyte count. Computed tomography (CT) of the thorax showed nodular sclerotic lesions, \>2 cm in diameter in bilateral carotid body regions, bilateral costal and axillary regions \[[Figure 2](#F2){ref-type=”fig”}\]. Whole body fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increased uptake of FDG in these lesions \[[Figure 3](#F3){ref-type=”fig”}\]. Ultrasound of abdomen and paraclinoid carotid angiogram showed no abnormality. Hence, a diagnosis of carotid body tumor with paraneoplastic pemphigus was made. ![Local examination showing increased pulsatile, and bright red blood vessels over bony prominences](IJEM-17-584-g001){#F1} ![Computed tomography of thorax showing nodular sclerotic lesions, \>2 cm in diameter in bilateral carotid body regions, bilateral costal and axillary regions](IJEM-17-584-g002){#F2} ![Whole body fluorodeoxyglucose-positron emission tomography/computed tomography showing increased uptake of fluorodeoxyglucose in these lesions](IJEM-17-584-g003){#F3} Carotid body tumors are slow growing and non-metastatic neoplasms.\[[@ref1][@ref2][@ref3]\] Carotid body tumors are characterized by rich vascularity, which makes them highly vascular in



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The game will run on the following minimum system requirements: OS: Windows 7, Windows 8, Windows 10 Processor: Intel i3-3110, AMD A10-7850K Memory: 2 GB RAM Graphics: Nvidia GeForce GTX 1050 or AMD Radeon HD 7850 DirectX: Version 11 Storage: 1 GB available space Sound Card: DirectX Compatible Flexible Mouse Interface (FMD), Keyboard Interface (FKD), Traditional Mouse Interface (TMD) Recommended system requirements:



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