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Windows 7 RemoveWAT v2.2.5.2 – Гравчанин 1.1.9.rar Versions: 6.03 Build 5.2 – Молодёжное.zip
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ArsDigita ILB Enhanced.rar 0 · A href=”” class=” Google Drive rar “>Too many – Гравчанин 1.1.9.rar Versions: 6.03 Build 5.2 – Молодёжное.zipStephen O’Grady (curler)

Stephen O’Grady (born 17 October 1970 in Montreal, Quebec) is a Canadian curler from Témiscaming, Quebec. He previously skipped the Sault Ste. Marie Curling Association men’s team from 1999 to 2001.

O’Grady is best known for winning the 1999 Canadian Mixed Curling Championship with partner Shelly Steele.

O’Grady represented Team Canada at the 2001 Pacific-Asia Curling Championships as lead for the fourth time. They won the bronze medal after losing in the semi-final to Japan’s team (Kaori Shinohara, Tomoko Fukunaga, Kana Yokoyama, Chihiro Takao).

O’Grady currently coaches the Bures Curling Club in Témiscaming.

Grand Slam record

Former events

References

External links

Category:1970 births
Category:Curlers from Quebec
Category:Living people
Category

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As an important member of the ABC transporter family, P-glycoprotein (P-gp) actively transports drugs from the blood into the intestinal lumen. The purpose of this study was to develop a quantitative structure-activity relationship (QSAR) model to explore the effect of the various interactions between drugs and P-gp. A set of 115 structurally diverse compounds, including hydrophilic and hydrophobic compounds and compounds of different molecular size, were tested. Correlation coefficients (r2), determination coefficients (Q2), distribution coefficients (LogD(P) or LogSbw), P-gp ATPase activity, and in vitro intestinal transport were the parameters used in the QSAR model. LogD(P) and the in vitro transport of P-gp substrates had a similar effect on the QSAR model, indicating that LogD(P) was the most sensitive descriptor for P-gp transport activity and was therefore selected for use in the model. The QSAR model generated from the 115 drugs was used to predict the pC50 (predictive concentration causing 50% reversal of P-gp ATPase activity) of new compounds. This model indicates that the transport activity of P-gp is a function of LogP (Log of the partition coefficient between octanol and water), molecular weight (MW), and LogD(P). Since MW is related to LogD(P) for the hydrophilic compounds, only these two parameters were considered in the model, which was subsequently validated with a set of 24 structurally similar compounds (7 hydrophilic and 17 hydrophobic compounds). The validated model suggests that LogP is more important for the transport activity of hydrophobic substrates. The transport activity of P-gp can be predicted for any compound by calculating the sum of their LogP (or Sbw) and MW using the model, and the calculated pC
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