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Natriuretic peptides are widely used as bedside biomarkers in several clinical applications, including monitoring, risk stratification, prognostication, treatment monitoring, and diagnosis of HF with reduced ejection fraction. The availability of measurement technologies that are able to measure peptide concentrations in serum, such as N-terminal pro-BNP, as well as of biomarker assays that are highly specific and have good precision, make N-terminal pro-BNP especially attractive.[@bib37] For example, the use of proBNP has been extended beyond the diagnostic process of HF and is increasingly being used for monitoring the response to treatment.[@bib38]
In summary, the data presented here indicate that the N-terminal proBNP assay is a highly specific method for the diagnosis of PAF, providing high negative predictive value, and an excellent NPV. This study has two important implications. First, we report on a cohort of individuals presenting to the ED for management of acute symptoms and syndromes, allowing us to provide a snapshot of the use of BNP-based biomarkers in emergency medicine. Second, the availability of BNP-based biomarkers for PAF allows physicians to make a definitive diagnosis of PAF in ED settings, thereby allowing rapid therapeutic interventions and more effective use of healthcare resources. The availability of a rapid
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